PANTODIL 40MG INJ

Pantoprazole 40 mg injection is a medication belonging to the class of proton pump inhibitors (PPIs). This formulation is designed for intravenous administration.

Uses

Pantoprazole is used in the treatment of heartburn, gastroesophageal reflux disease (acid reflux) and peptic ulcer disease.

Side Effects

Diarrhea, Flatulence, Headache, Nausea, Vomiting, Dizziness, Abdominal pain, Joint pain, Injection site reaction

How to Use

“Pantoprazole should be taken 1 hour before a meal, preferably in the morning. It is a well-tolerated medicine and provides relief for a long time.

How it Works

“Hydrochloric acid (HCl) secretion into the gastric lumen is a process regulated mainly by the H(+)/K(+)-ATPase of the proton pump, expressed in high quantities by the parietal cells of the stomach. ATPase is an enzyme on the parietal cell membrane that facilitates hydrogen and potassium exchange through the cell, which normally results in the extrusion of potassium and formation of HCl (gastric acid). Proton pump inhibitors such as pantoprazole are substituted benzimidazole derivatives, weak bases, which accumulate in the acidic space of the parietal cell before being converted in the canaliculi (small canal) of the gastric parietal cell, an acidic environment, to active sulfenamide derivatives. This active form then makes disulfide bonds with important cysteines on the gastric acid pump, inhibiting its function.

Fact Box

Interactions with Drugs

• • 1. Pantoprazole may decrease the excretion rate of Abacavir which could result in a higher serum level.

• • 2. The serum concentration of Pantoprazole can be increased when it is combined with Abametapir.

• • 3. The metabolism of Pantoprazole can be increased when combined with Abatacept.

• • 4. Pantoprazole may decrease the excretion rate of Abemaciclib which could result in a higher serum level.

• • 5. The metabolism of Abrocitinib can be decreased when combined with Pantoprazole.

Quick Tips

“Pantoprazole should be taken 1 hour before a meal, preferably in the morning. It is a well-tolerated medicine and provides relief for a long time. Some healthy tips to prevent acidity from happening: Avoid excessive intake of carbonated beverages/soft drinks, citrus juices, fried food, caffeinated beverages like tea and coffee. Avoid alcohol and smoking. Avoid eating late at night or before bedtime. Inform your doctor if you get watery diarrhea, fever or stomach pain that does not go away. Inform your doctor if you do not feel better after taking it for 14 days as you may be suffering from some other problem that needs attention.”